Most of cell lines inoculated in the chick chorioallantoic membrane (CAM) model from fast growing tumours, whereas prostate tumours do not. Vascularised prostate tumours formed in two days, without sibsequent volume increase.
The understanding of this growth arrest coul deepen knowledge about prostate tumour development and the involved factors and potentially bring new therapy hints.
The goal will be to understand the growth arrest of prostate tumours implanted in the CAM and the implication of scavenger receptor BI (SR-BI) in this process. Expression of SR-BI and other proteins of interest will be analyzed in the prostate tumours in the CAM. Ultimately SR-BI will be used to deliver anti-cancer agents and antioxidants to cancer cells via synthetic reconstituted HDL.
PRINCIPAL APPLICANT :
Anne Perez, Biologiste. Unité de nutrition, Hôpitaux Universitaires de Genève.